This workshop will review recent trends associated with methamphetamine in the United States. Specifically, changes in prevalence of methamphetamine use will be discussed, as well as observed changes in the methamphetamine product itself (e.g. potency, purity, price) which may have an impact on psychosis. Background on the clinical characteristics of methamphetamine-associated psychosis (MAP) will be explored, as well as its association with schizophrenia, and its hypothesized pathophysiology. Clinical strategies to differentiate MAP from schizophrenia will also be provided. Treatment approaches to MAP will be described, ranging from a general review of evidence-based treatments for MUD, to specific treatments for the psychotic symptoms within MAP. Finally, panel members will share perspectives on the clinical approach to MAP informed by experience and a mix of published and unpublished data.