Concurrent Paper Session C-Concurrent Paper Session C

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Video Summary

In the recent paper presentation by Dr. Aquino, an assistant professor of psychiatry at Yale, he delved into the modulation of pain sensitivity using Delta-9 tetrahydrocannabinol (THC) among individuals undergoing opioid agonist therapy for opioid use disorder. Dr. Aquino's study is a within-subject, randomized, placebo-controlled trial that examined the acute effects of oral THC on pain, abuse potential, and cognitive performance among individuals treated with methadone. The study found preliminary evidence for analgesic effects of THC at lower doses, though it was not statistically significant in improving pain threshold or tolerance. The study noted modest evidence of abuse potential and cognitive deficits, particularly in verbal memory. Dr. Aquino underscored the importance of understanding the impact of attitude changes towards cannabinoids, particularly as many patients with opioid use disorder also suffer from chronic pain. Most states with medical cannabis laws have listed pain as the most qualifying condition, creating a complex environment for those treating opioid use disorder. The study's insights advocate for rigorous clinical trials to understand the implications of THC exposure during opioid treatment. Additionally, Dr. Aquino highlighted the interplay between cannabinoid and opioid receptors, suggesting the potential for cannabinoids to complement opioid therapy, thus serving as a groundbreaking step in understanding pain management in this demographic. The presentation concluded with acknowledgments to the study participants, funding bodies, and the academic team supporting this research endeavor.

Keywords

cannabinoids

THC

chronic pain

opioid use disorder

Dronabinol

opioid overdose

fentanyl

medical cannabis

methadone

biphasic effects

pain sensitivity

Delta-9 tetrahydrocannabinol

opioid agonist therapy

cognitive performance

analgesic effects

cannabinoid receptors

methadone treatment

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