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35th AM (2025) - Poster Session
The Nutmeg High A Study of Self-Reported Experienc ...
The Nutmeg High A Study of Self-Reported Experiences on Online Forums
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This study examines the recreational use of nutmeg, focusing on the "nutmeg high" by analyzing self-reported experiences primarily sourced from online forums like Reddit. Nutmeg contains myristicin, a compound with psychoactive and anticholinergic effects. Myristicin can be metabolized into an amphetamine-like substance, mildly inhibit monoamine oxidase, antagonize GABA receptors (potentially causing anxiety), and inhibit enzymes that degrade endocannabinoids, possibly producing cannabis-like effects. Despite widespread recreational use, detailed clinical understanding is limited, and nutmeg use is not detectable via standard urine drug screens, complicating clinical recognition.<br /><br />The study aimed to describe perceived positive effects, identify common side effects, and evaluate motivations for nutmeg use. Analysis revealed a delayed onset and prolonged duration of effects with fluctuating intensity. About 62% of experiences were perceived as positive, 19% negative, and 16% neutral; 3% were difficult to assess due to incoherent thought processes. Positive effects included insight, feelings of connectedness, increased energy and focus, enhanced creativity, sexual arousal, and confidence. Negative effects commonly involved impaired short-term memory, paranoia, muscle/joint pain (myalgias), respiratory symptoms, sweating, tinnitus, feelings of doom, and psychotic-like symptoms such as delusions and disorganized thoughts. Other reported effects resembled those induced by substances like alcohol, psychedelics, dextromethorphan, and MDMA.<br /><br />Motivations for use, reported in 12 posts, included its legal status, easy accessibility, low cost, peer influence, and boredom, underscoring the need for education regarding its potential dangers.<br /><br />Limitations of the study include reliance on subjective, self-reported data, which may involve inaccuracies or bias. Nonetheless, the findings enhance clinical awareness of nutmeg intoxication presenting with mood and psychotic symptoms, crucial for acute patient assessment and highlight the importance of recognizing musculoskeletal pain as a lesser-known effect.
Keywords
nutmeg high
myristicin
psychoactive effects
anticholinergic effects
recreational drug use
self-reported experiences
clinical recognition challenges
positive and negative effects
motivation for use
nutmeg intoxication symptoms
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