34th AM (2023) - Poster Session-A Retrospective Analysis of Healthcare Resource Utilization and Costs Associated With Use of Extended-Release Naltrexone Among Commercially Insured Patients with Opioid Dependence

A Retrospective Analysis of Healthcare Resource Utilization and Costs Associated With Use of Extended-Release Naltrexone Among Commercially Insured Patients with Opioid Dependence

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This document is a summary of a retrospective observational study that examines the healthcare resource utilization (HRU) and costs associated with the use of extended-release naltrexone (XR-NTX) among commercially insured patients with opioid dependence. The study found that greater XR-NTX persistence was associated with reductions in detoxification-related services and costs, as well as reductions in all-cause acute-care utilization. The study also observed increases in all-cause outpatient utilization, including drug costs, indicating an improvement in the continuity of care.<br /><br />The study used data from the Merative MarketScan Commercial Claims and Encounters Database from 2010 to 2019. The analysis included 7,270 patients who initiated XR-NTX following an opioid dependence diagnosis. The patients were categorized based on the number of XR-NTX injections they received.<br /><br />The results showed that patients who received 2 or more XR-NTX injections had reductions in monthly emergency department visits, inpatient admissions, and inpatient days compared to patients who received only 1 injection. However, there were increases in monthly outpatient visits and outpatient pharmacy prescriptions with greater XR-NTX persistence.<br /><br />In terms of costs, patients who received 2 or more injections had reductions in monthly acute-care costs, particularly in terms of inpatient admission costs. The study also found that total monthly healthcare costs decreased with greater XR-NTX persistence, despite increases in outpatient utilization costs.<br /><br />The study acknowledges some limitations, including potential bias due to unmeasured confounding factors and the relatively small sample size in the higher injection categories.<br /><br />In conclusion, the study suggests that increased XR-NTX persistence is associated with reductions in detoxification-related services and costs, as well as all-cause acute-care utilization. These findings highlight the potential benefits of XR-NTX in the treatment of opioid dependence. However, further research is needed to better understand the impact of treatment persistence on patient outcomes and to inform treatment decisions.

Keywords

observational study

healthcare resource utilization

costs

extended-release naltrexone

XR-NTX

opioid dependence

detoxification-related services

all-cause acute-care utilization

outpatient utilization

injections

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