2021 AM Posters-Potential of Mat beyond Treatment of Opioid Use disorder

Potential of Mat beyond Treatment of Opioid Use disorder

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A systematic review and meta-analysis conducted by Thomas Santos Jr., MPH, Brodie Clark, and others evaluated the association of medication-assisted treatment (MAT) with cause-specific mortality among people with opioid dependence. The study included 15 randomized clinical trials and 36 primary cohort studies, with a total of 3,852 participants and 749,634 participants, respectively.<br /><br />The results showed that individuals receiving MAT had a significantly lower risk of all-cause mortality, overdose mortality, suicide mortality, cancer mortality, drug-related mortality, alcohol-related mortality, and cardiovascular-related mortality compared to those not receiving MAT. The rate of all-cause mortality during MAT was less than half the rate during periods off MAT. This association held true for both buprenorphine and methadone MAT.<br /><br />It was also found that the risk of all-cause mortality is highest in the 4-week period following cessation of treatment. This highlights the importance of continuing MAT for long-term treatment of opioid dependence to reduce mortality risk.<br /><br />MAT, specifically with buprenorphine, naltrexone, and methadone, is a recommended and effective treatment for opioid use disorder. However, regulatory barriers to prescribing these medications limit their use in practice. Clinicians in any specialty should have an understanding of the benefits, side effects, and interactions of MAT medications due to the increasing prevalence of opioid use disorder.<br /><br />In conclusion, this study provides evidence for the beneficial effects of MAT on reducing mortality among individuals with opioid dependence. MAT should be considered as a critical treatment option for opioid use disorder to improve patient outcomes and reduce mortality.

Keywords

systematic review

meta-analysis

medication-assisted treatment

MAT

cause-specific mortality

opioid dependence

all-cause mortality

overdose mortality

suicide mortality

cancer mortality

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