2021 AM Posters-Cannabidiol and Substance Use Disorders An Update on Evidence

Cannabidiol and Substance Use Disorders An Update on Evidence

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The article discusses the potential of cannabidiol (CBD) as a treatment for substance use disorders. Currently, there are no FDA-approved medications for the treatment of many drug use disorders. CBD is considered a safe option with limited abuse potential. It regulates dopamine in the reward pathway and shows promise in the treatment of all substance use disorders.<br /><br />The authors conducted a search for relevant studies on CBD and substance use disorders. They found a total of seven studies that met their criteria. The studies focused on nicotine, cannabis, heroin, and cocaine use disorders.<br /><br />The results of the studies showed that CBD was beneficial in the treatment of cannabis, heroin, and nicotine use disorders. It showed a significant decrease in the number of cigarettes smoked and cravings for nicotine. CBD also reversed attentional bias to cigarette cues in abstinent smokers. However, it did not improve cognition or reduce cravings for cocaine.<br /><br />The limitations of the current trials include short duration of intervention and follow-up, limited endpoints, and a lack of research on substances like alcohol, benzodiazepines, and methamphetamine.<br /><br />CBD has the potential to be a novel therapy in addiction treatment with substantial public health benefits. It is widely available over the counter and requires little monitoring. Further research into its mechanism of action could lead to more targeted therapies with fewer side effects.<br /><br />Overall, CBD shows promise as a treatment option for substance use disorders, particularly for cannabis, heroin, and nicotine use disorders. However, more research is needed to explore its efficacy in treating other substances and to address the limitations of current trials.

Keywords

cannabidiol

CBD

substance use disorders

FDA-approved medications

dopamine regulation

reward pathway

nicotine use disorder

cannabis use disorder

heroin use disorder

cocaine use disorder

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